During the reign of the third shogun, Tokugawa Iemitsu, an infectious disease called red smallpox spreads only among young men, causing the population of males in the country to plummet to one-fourth that of the population of females. Iemitsu himself passes away suddenly of this illness too. Fearing that the Tokugawa bloodline would be cut off, Iemitsu’s wet nurse Kasuga no Tsubone sends for a young girl whom Iemitsu sired outside Edo Castle, makes her dress as a boy and secretly brings her up as the shogun within the castle’s inner palace. When the girl is 13, she is violated by a bodyguard who is later beheaded. After that, the girl will not open her heart to anyone. When she turns 16 as Tokugawa Iemitsu, Kasuga no Tsubone forcibly detains the monk Madenokoji Arikoto who has come to Edo from Kyoto and presses him to return to secular life. Together with his disciple Gyokuei, Arikoto is made to serve in the inner palace as Iemitsu’s attendant. In an audience with Iemitsu, Arikoto is astonished to realise that the shogun is a female.
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Mitamura Yukio (Sawamura Ikki) is the founder and president of a rapidly growing apparel company. Mitamura places priority on the company’s profits and overworks his employees. He justifies this with the belief that hard work is necessary to achieve results. He does not think his beloved company exploits its employees. Mitamura enrolls in a university to study company management from the basics. This is where he meets a new lecturer Akiyama Kyoko (Kuroki Meisa). Although he feels attracted to the intellectual Kyoko, the differences in their way of thinking results in frequent clashes. Within the company while Mitamura is in college there is an attempt to oust him from his company. With the knowledge he has gained from attending university classes Mitamura soon realizes that his company does indeed exploit its employees. A power struggle soon begins inside the company.
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Onizuka Eikichi goes from Meishu Academy in Kichijoji to his alma mater Tsujido High School in his hometown of Shonan. Tsujido High School has gone under the umbrella of Meishu Academy and Onizuka is dispatched on a temporary basis. This time, various difficult problems such as a pregnant female high school student, a truant student who makes light of life, a male stalker and radical images happen to him. Onizuka’s unknown past is also finally revealed as he meets people who know about his past again...
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Matsumoto Mao is suppose to become the new medical examiner and visit the USA at the age of 10. While there she is to study advanced placement 3rd year Forensics. she has an IQ of over 150. Suddenly she becomes like an ordinary person confusing everybody, except Kyoko. A rush of bodies come in for autopsy. A middle aged man who apparently fell for a scaffolding at a construction site comes in. Mao begins the autopsy without a speck of the days exhaustion showing. She discoveries that he did not simply head his head while falling. Case impending..
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Shiba Kentaro is a compassionate vet in an old Tokyo neighborhood. He doesn't only treat pets, but also interferes in the problems of pet owners and struggles to be of help.